Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir. Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/γc null mice: suppression by an Inhibitor against NF-kappaB. Severe combined immunodeficiency (SCID) in the mouse. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Intra-thymic/splenic engraftment of human T cells in HLA-DR1 transgenic NOD/scid mice. Immunodeficiency Rev 3:261–276.Ĭamacho, R. B and T cell leakiness in the scid mouse mutant. A severe combined immunodeficiency mutation in the mouse. Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes. Mapping of the X-linked immune deficiency mutation (xid) of CBA/N mice. HIV-1 infection and CD4 T cell depletion in the humanized Rag2 −/−gamma c −/− (RAG-hu) mouse model. Dwarf mice produced by genetic ablation of growth hormone-expressing cells. Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2 −/−gamma c −/− mice. The IFN gamma receptor: a paradigm for cytokine receptor signaling. This process is experimental and the keywords may be updated as the learning algorithm improves.īach, E. These keywords were added by machine and not by the authors. In addition, we also describe the potential development of new immunodeficient mice that can be used as humanized mice in the future. This review describes the history and characteristics of the NOD/Shi- scid IL2rγ null (NOG) and BALB/cA- Rag2 null IL2rγ null mice that were established in Japan, including our unpublished data from researchers who are currently using these mice. This work has attracted attention worldwide, but the development and use of immunodeficient mice in Japan are not very well known or understood. Using the newly combined immunodeficient NOD- scid IL2rγ null mice and Rag2 null IL2rγ null humanized mice, it has became possible to expand applications because various hematopoietic cells can be differentiated by human hematopoietic stem cell transplantation, and the human immune system can be reconstituted to some degree. “Humanized mice,” in which various kinds of human cells and tissues can be engrafted and retain the same functions as in humans, are extremely useful because human diseases can be studied directly.
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